# STOCKHOLM 1.0
#=GF                  AC RF00027
#=GF                  ID let-7
#=GF                  DE let-7 microRNA precursor
#=GF                  AU Griffiths-Jones SR
#=GF                  SE Griffiths-Jones SR
#=GF                  SS Predicted; PFOLD
#=GF                  GA 11.00
#=GF                  TC 11.66
#=GF                  NC 0.11
#=GF                  TP Gene; miRNA;
#=GF                  BM cmbuild CM SEED
#=GF                  BM cmsearch -W 150 CM SEQDB
#=GF                  RN [1]
#=GF                  RM 11533718
#=GF                  RT Control of developmental timing in animals.
#=GF                  RA Rougvie AE;
#=GF                  RL Nat Rev Genet 2001;2:690-701.
#=GF                  RN [2]
#=GF                  RM 11779458
#=GF                  RT microRNAs: tiny regulators with great potential.
#=GF                  RA Ambros V;
#=GF                  RL Cell 2001;107:823-826.
#=GF                  CC This family represents the microRNA (miRNA) let-7. let-7 was identified 
#=GF                  CC from a study of developmental timing in C. elegans [1], and was
#=GF                  CC later shown to be part of a much larger class of non-coding RNAs
#=GF                  CC termed miRNAs [2].  miRNAs are transcribed as ~70nt precursors
#=GF                  CC (modelled here) and subsequently processed by the Dicer enzyme
#=GF                  CC to give a ~22nt product.  The extents of the hairpin precursors
#=GF                  CC are not generally known and are estimated based on hairpin 
#=GF                  CC prediction.  The products are thought to have
#=GF                  CC regulatory roles through complementarity to mRNA.  The involvement
#=GF                  CC of Dicer in miRNA processing suggests a relationship with the 
#=GF                  CC phenomenon of RNA interference.  This family also includes the 
#=GF                  CC miR-98 precursor from human, which may be a let-7 homologue.
#=GF                  SQ 12
#=GC             SS_cons <<<<<<.<<<<<<<<<<<<<<<<<<<<<....<<<<..........>>>>.....
AP001359.4/114553-114478 CCAGGUUGAGGUAGUAGGUUGUAUAGUUU..A.GA.....AUUACA.UC.....A
  AC094021.2/47340-47253 CCAGGCUGAGGUAGUAGUUUGUACAGUUUG.AGGGUCUAUGAUACCACCC.GGUA
AP000962.2/118093-118168 CCGGGUUGAGGUAGUAGGUUGUAUGGUUU..AGAGU.......UACACCC.....
   AC048341.22/3536-3622 CCUGGCUGAGGUAGUAGUUUGUGCUGUUGGUCGGGU.UGUGACAUUGCCC..GCU
AC018755.3/119936-120011 CCGGGCUGAGGUAGGAGGUUGUAUAGUU....GAGG....AGGACACC.C.....
 AL158152.18/40779-40863 CUAGGAAGAGGUAGUAGGUUGCAUAGUUUU.AGGGC.AGGGAUUUUGCCC...AC
 AL158152.18/38291-38377 UCAGAGUGAGGUAGUAGAUUGUAUAGUUGU.GGGGU.AGUGAUUUUACCC.UGUU
 AL158152.18/37901-37981 .UGGGAUGAGGUAGUAGGUUGUAUAGUUUU.AGGGU.......CACACCCACCAC
  AL049853.1/17069-16987 .CGGGGUGAGGUAGUAGGUUGUGUGGUUUC.AGGGC.AGUGAUGUUGCCC...CU
  AL049853.1/18009-17931 UUGGGGUGAGGUAGUAGGUUGUAUAGUUUG..GGGC.......UCUGCCC..UGC
    AF210771.1/1883-1955 UACGGU.GAGGUAGUAGGUUGUAUAGUUU..AGAAU.......AUUACUC.....
    Z70203.2/12451-12379 UCCGGU.GAGGUAGUAGGUUGUAUAGUU....UGG....AAUAUUA.CCA.....

#=GC             SS_cons ........>>>>>>>>>>>>>>>>>>>>>>>>>>>
AP001359.4/114553-114478 AGGGAGAUAACUGUACAGCCUCCUAGCUUUCCUUG
  AC094021.2/47340-47253 CAGGAGAUAACUGUACAGGCCACUGCCUUGCCAGG
AP000962.2/118093-118168 UGGGAGUUAACUGUACAACCUUCUAGCUUUCCUUG
   AC048341.22/3536-3622 GUGGAGAUAACUGCGCAAGCUACUGCCUUGCUAGU
AC018755.3/119936-120011 AAGGAGAUCACUAUACGGCCUCCUAGCUUUCCCCA
 AL158152.18/40779-40863 AAGGAGGUAACUAUACGACCUGCUGCCUUUCUUAG
 AL158152.18/38291-38377 CAGGAGAUAACUAUACAAUCUAUUGCCUUCCCUGA
 AL158152.18/37901-37981 UGGGAGAUAACUAUACAAUCUACUGUCUUUCCUAA
  AL049853.1/17069-16987 CGGAAGAUAACUAUACAACCUACUGCCUUCCCUG.
  AL049853.1/18009-17931 UAUGGGAUAACUAUACAAUCUACUGUCUUUCCUGA
    AF210771.1/1883-1955 UCGGUG..AACUAUGCAAGUUUCUACCUCACCGAA
    Z70203.2/12451-12379 CCGGUG..AACUAUGCAAUUUUCUACCUUACCGGA

//